Irritability about book in religious literary collection (5)
I believe the answer is:
bible
'religious literary collection' is the definition.
'irritability about book' is the wordplay.
'irritability' becomes 'bile'.
'about' indicates putting letters inside.
'book' becomes 'b'.
'bile' enclosing 'b' is 'BIBLE'.
'in' is the link.
(Other definitions for bible that I've seen before include "See 12" , "reliable work" , "Book of the Scriptures" , "It contains scriptures" , "Holy Writ" .)