Crossword Genius

Irritate with a hypodermic (6)

Ross

I believe the answer is:

needle

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'irritate' is the definition.
(I know that needle is a more specific form of beset)

I can't explain the rest of the clue.

Can you help me to learn more?

(Other definitions for needle that I've seen before include "Sewer's implement" , "pinnacle of rock" , "Badger with sewing implement" , "Rile" , "one of many on Christmas tree" .)

I've seen this clue in The Mirror.
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