Irritate with hypodermic (6)
I believe the answer is:
needle
This clue could be a double definition.
'irritate' is the first definition.
(I know that needle is a more specific form of beset)
'hypodermic' is the second definition.
The definition and answer can be both man-made objects as well as being singular nouns.
Perhaps they are linked in a way I don't understand?
'with' is the link.
Can you help me to learn more?
(Other definitions for needle that I've seen before include "Instrument to annoy" , "It's difficult to find one in a haystack" , "Annoy, tantalise" , "Thin pointer; antagonise" , "Implement for knitting and sewing" .)