Irritated and out of bed following injury (5,2)
I believe the answer is:
wound up
'irritated' is the definition.
(to wind someone up is to annoy them)
'out of bed following injury' is the wordplay.
'out of bed' becomes 'up' (synonyms).
'following' means one lot of letters go next to another.
'injury' becomes 'wound' (synonyms).
'up' after 'wound' is 'WOUND-UP'.
'and' is the link.
(Other definitions for wound up that I've seen before include "Overwrought" , "Angry" , "Irritated - ended" , "Teased" , "excited" .)