Issue great healer raised (4)
I believe the answer is:
emit
'issue' is the definition.
(thesaurus)
'great healer raised' is the wordplay.
'great healer' becomes 'time' (reference to the phrase 'time is a great healer').
'raised' says the letters should be written in reverse.
'time' in reverse letter order is 'EMIT'.
(Other definitions for emit that I've seen before include "Give off or discharge" , "Sent" , "Come out!" , "Send forth" , "Produce and discharge" .)