It can make you look frowning or wry, somehow (5)

I believe the answer is:

worry

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'it can make you look frowning' is the definition.
The definition suggests a singular noun which matches the answer.

'or wry somehow' is the wordplay.
'somehow' is an anagram indicator.
'or'+'wry'='orwry'
'orwry' with letters rearranged gives 'WORRY'.

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(Other definitions for worry that I've seen before include "'Anxiety, uneasiness (5)'" , "Harry" , "Bother" , "(Feel) anxiety" , "Fret, be disturbed in mind" .)

I've seen this clue in the Evening Standard.

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