It can react jerkily (4)
I believe the answer is:
knee
'it can react jerkily' is the definition.
The definition suggests a singular noun which matches the answer.
This is all the clue.
Can you help me to learn more?
(Other definitions for knee that I've seen before include "Technical name for this joint is genu" , "Hinge joint" , "Thigh/shin connector" , "Capped joint?" , "Joint protected by the patella" .)