It matters little that it's sweet (6)
I believe the answer is:
trifle
'sweet' is the definition.
(I know that trifle is a type of sweet)
'it matters little that its' is the wordplay.
I cannot really understand how this works, but
'it' could be 't' (abbreviation. e.g. in 'tis) and 't' is located in the answer.
'little' could be 'l' (abbreviation for little) and 'l' is located in the answer.
The remaining letters 'rife' is a valid word which might be clued in a way I don't understand.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for trifle that I've seen before include "Triviality" , "A small portion" , "Possible component of meal" , "Filter (anag.)" , "Thing of little value or importance" .)