It's a risky business for egomaniacs losing game (6)
I believe the answer is:
casino
'game' is the definition.
(I have seen 'game of cards' mean 'casino' so perhaps 'game' could also mean 'casino')
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for casino that I've seen before include "Gaming house" , "where one can lose a lot of money" , "You can win a fortune here" , "Gambling emporium" , "Gambling venue" .)