It's impossible, note, to invest in new food e-tailer (2,3,2)
I believe the answer is:
no can do
'it's impossible' is the definition.
('no can do' can mean something is impossible)
'note to invest in new food e-tailer' is the wordplay.
I cannot quite understand how this works, but
'note' could be 'do' (as in do-re-mi) and 'do' is found in the answer.
'new' could be 'n' (common abbreviation eg NT for New Testament) and 'n' is located in the answer.
'food' could be 'a' (A is an example) and 'a' is present in the answer.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for no can do that I've seen before include "That's not possible" , "Unable to help" , "Nothing manageable" , "Informal expression of refusal" , "That's out of the question!" .)