It’s not to be sniffed at! (4)
I believe the answer is:
glue
'at' is the definition.
The answer and definition can be both substances as well as being singular nouns.
Maybe they are linked in a way I don't understand?
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for glue that I've seen before include "Adhesive stuff" , "Paste" , "size" , "Sticky substance" , "Stick together" .)