Journey heading for Florence, easy (6)
I believe the answer is:
flight
'journey' is the definition.
(I know that flight is a type of journey)
'heading for florence easy' is the wordplay.
'heading for' suggests taking the first letters.
'easy' becomes 'light' (similar in meaning).
The initial letter of 'florence' is 'f'.
'f'+'light'='FLIGHT'
(Other definitions for flight that I've seen before include "Air force unit; running away" , "Group of birds - running away" , "The feathers on a dart or arrow" , "Fleeing" , "the vanquished may take?" .)