Lament matter suffering ill-use (12)
I believe the answer is:
maltreatment
'ill-use' is the definition.
(thesaurus)
'lament matter suffering' is the wordplay.
'suffering' is an anagram indicator.
'lament'+'matter'='lamentmatter'
'lamentmatter' is an anagram of 'MALTREATMENT'.
(Other definitions for maltreatment that I've seen before include "Cruel handling" , "Cruel behaviour" , "Ill-usage" .)