Crossword Genius

Large instrument's mouthpiece (5)

Ross

I believe the answer is:

organ

This clue is a double definition.

'large instrument's' is the first definition.
(I've seen this before)

'mouthpiece' is the second definition.
(I've seen this before)

(Other definitions for organ that I've seen before include "Eg, heart, liver" , "Medium; body part" , "What makes use of full stops" , "Part with special function" , "stops on one" .)

I've seen this clue in The Telegraph.
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