Left port with a full cargo (5)
I believe the answer is:
laden
'a full cargo' is the definition.
(I've seen this before)
'left port' is the wordplay.
'left' becomes 'l' (common abbreviation).
'port' becomes 'aden' (port in Yemen).
'l'+'aden'='LADEN'
'with' is the link.
(Other definitions for laden that I've seen before include "'Burdened, oppressed (5)'" , "Heavily weighed down" , "charged a lot" , "Weighed down with much cargo" , "Freighted" .)