Little things that can have ill effects (5)

I believe the answer is:
germs
'effects' is the definition.
The answer and definition can be both related to thinking as well as being plural nouns.
Perhaps you can see a link between them that I can't see?
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for germs that I've seen before include "Bacteria" , "Causes of disease" , "Starts" , "Seeds; microbes" , "Bugs" .)
