Live with distress and regret (6)
I believe the answer is:
bewail
'regret' is the definition.
(synonyms)
'live with distress' is the wordplay.
'live' becomes 'be' (synonyms).
'with' becomes 'w' (abbreviation).
'distress' becomes 'ail' (ail can mean to trouble or distress).
'be'+'w'+'ail'='BEWAIL'
'and' is the link.
(Other definitions for bewail that I've seen before include "Greatly lament" , "Cry over, mourn for" , "Goose-liver pate" , "Express grief" , "Moan" .)