Lives comfortably in Dumfries outskirts (6)
I believe the answer is:
dwells
'lives' is the definition.
('dwell' can be a synonym of 'live')
'comfortably in dumfries outskirts' is the wordplay.
'comfortably' becomes 'well' (synonyms).
'in' indicates putting letters inside.
'outskirts' says to hollow out the word (remove centre letters) (I've seen 'outskirts of' mean this).
'dumfries' with its middle taken out is 'ds'.
'well' placed into 'ds' is 'DWELLS'.
(Other definitions for dwells that I've seen before include "pauses" , "Lodges or resides" , "Lives in, inhabits" , "Establishes oneself" .)