Loathing wrong thread (6)
I believe the answer is:
hatred
'loathing' is the definition.
(I've seen this before)
'wrong thread' is the wordplay.
'wrong' is an anagram indicator.
'thread' with letters rearranged gives 'HATRED'.
(Other definitions for hatred that I've seen before include "Extreme dislike and enmity" , "Detestation, loathing" , "Violent emotion" , "Deep dislike and aversion" , "Intense dislike" .)