Locker pays attention to main themes (8)
I believe the answer is:
keynotes
'main themes' is the definition.
'keynotes' can be an answer for 'themes' (keynote is a kind of theme). I am unsure of the 'main' bit.
'locker pays attention' is the wordplay.
'locker' becomes 'key' (I've seen this before).
'pays attention' becomes 'notes' (I've seen this before).
'key'+'notes'='KEYNOTES'
'to' is the link.
Can you help me to learn more?
(Other definitions for keynotes that I've seen before include "Main musical notes or underlying themes" , "Central principles" , "Principal themes, central ideas" , "Prevailing ideas" .)