Lois is involved with five big fiddles (5)
I believe the answer is:
viols
'big fiddles' is the definition.
The answer and definition can be both man-made objects as well as being plural nouns.
Perhaps you can see a link between them that I can't see?
'lois is involved with five' is the wordplay.
'is involved with' is an anagram indicator.
'five' becomes 'v' ('V' can be a synonym of 'five').
'lois' mixed up with 'v' makes 'VIOLS'.
Can you help me to learn more?
(Another definition for viols that I've seen is " Old instruments".)