Looking to keep home that houses nothing innovative (10)
I believe the answer is:
pioneering
'innovative' is the definition.
(both can mean groundbreaking)
'looking to keep home that houses nothing' is the wordplay.
'looking' becomes 'peering' (peering is a kind of looking).
'to keep' indicates putting letters inside.
'home' becomes 'in' ('he's home' can mean 'he's in').
'that houses' indicates putting letters inside.
'nothing' becomes 'O' (looks like zero - 0).
'in' placed around 'o' is 'ion'.
'peering' going around 'ion' is 'PIONEERING'.
(Another definition for pioneering that I've seen is " Opening up (new terrain)".)