Lose heart, as pride injured (7)
I believe the answer is:
despair
'lose heart' is the definition.
(thesaurus)
'as pride injured' is the wordplay.
'injured' is an anagram indicator.
'as'+'pride'='aspride'
'aspride' with letters rearranged gives 'DESPAIR'.
(Other definitions for despair that I've seen before include "An unhappy state" , "Hopeless" , "Smashed up" , "A spider (anag.)" , "The feeling that nothing will turn out well" .)