Crossword Genius

The insecure should, when they lose heart (6)

Ross

I believe the answer is:

insure

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If this is the answer, I'm afraid I cannot explain it.

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(Other definitions for insure that I've seen before include "Rue sin (anag)" , "Protect (something) against loss" , "Protect by taking out a policy" , "Protect against possible loss" , "do business at Lloyds?" .)

I've seen this clue in The Globe and Mail.
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