Losing head, drunk's crazy bringing in company to open bottle (6)
I believe the answer is:
uncork
'open bottle' is the definition.
(I've seen this before)
'losing head drunk's crazy bringing in company' is the wordplay.
'losing head' means to remove the first letter.
'crazy' indicates an anagram.
'bringing in' means one lot of letters goes inside another.
'company' becomes 'co' (abbreviation).
'drunk' with its first letter taken off is 'runk'.
'runk' with letters rearranged gives 'unrk'.
'unrk' going around 'co' is 'UNCORK'.
'to' is the link.
(Other definitions for uncork that I've seen before include "Open (a wine bottle)" , "open tent?" , "Remove traditional stopper from wine bottle" , "Open (Chablis, say)" , "Clear a bottleneck" .)