Low point, coming from Barcelona direction (5)
I believe the answer is:
nadir
'low point' is the definition.
(I've seen this before)
'coming from barcelona direction' is the wordplay.
'coming from' indicates the answer is hidden within the clue.
'NADIR' can be found hidden inside 'barcelona direction'.
(Other definitions for nadir that I've seen before include "most unsuccessful point" , "You can't sink lower!" , "The lowest point of anything" , "Low point" , "lowest of the low" .)