Magic practitioner has wife turned into large reptile (6)
I believe the answer is:
lizard
'reptile' is the definition.
(lizard is a kind of reptile)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for lizard that I've seen before include "Reptile such as skink" , "Type of reptile" , "Gecko, for example" , "Two-legged reptile" , "Gecko, chameleon or monitor?" .)