Main problem for the Brexiteers (5,3)
I believe the answer is:
irish sea
'main' is the definition.
(I've seen this before)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for irish sea that I've seen before include "It separates Ireland from Britain" , "Man's situation" , "Main" , "Waters separating Ireland from England and Wales" , "It separates Ireland from England and Wales" .)