Male advanced women's complaints (8)
I believe the answer is:
maladies
'complaints' is the definition.
(I've seen this before)
'male advanced women's' is the wordplay.
'male' becomes 'm' (common abbreviation).
'advanced' becomes 'a'.
'women' becomes 'ladies' (lady is a kind of woman**).
'm'+'a'+'ladies'='MALADIES'
(Other definitions for maladies that I've seen before include "Diseases, ailments" , "Complaints" , "illnesses" .)