Males ran witch hunt site (5)
I believe the answer is:
salem
'witch hunt site' is the definition.
(site of Salem witch trials)
'males ran' is the wordplay.
'ran' is an anagram indicator (letters have run around).
'males' with letters rearranged gives 'SALEM'.
(Other definitions for salem that I've seen before include "Witch trial town" , "American capital" , "Capital of Oregon, USA" , "Meals (anag.)" , "Massachusetts city associated with the execution of witches" .)