Man depressed requires permit (5)
I believe the answer is:
allow
'permit' is the definition.
(I know that allow is a kind of permit)
'man depressed' is the wordplay.
'man' becomes 'al' (man's name).
'depressed' becomes 'low' (synonyms).
'al'+'low'='ALLOW'
'requires' is the link.
(Other definitions for allow that I've seen before include "Tolerate" , "Admit as acceptable" , "Permit, let happen" , "Sanction" , "Permit or agree" .)