Manual work for female graduate (6)
I believe the answer is:
alumna
'female graduate' is the definition.
(I've seen this before)
'manual work' is the wordplay.
'work' indicates an anagram.
'manual' with letters rearranged gives 'ALUMNA'.
'for' acts as a link.
(Other definitions for alumna that I've seen before include "Manual (anag) - old girl" , "Female graduate" , "Harvard graduate" , "Female former pupil" , "She studied" .)