Maybe Minneapolis lost its main character (7)
I believe the answer is:
epsilon
'character' is the definition.
(epsilon is a kind of letter of the alphabet)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for epsilon that I've seen before include "character in Greece" , "Greek character" , "foreign letter" , "Fifth letter of the Greek alphabet" , "Greek letter E" .)