Meaning to go north in the southeast again! (5)
I believe the answer is:
sense
'meaning' is the definition.
(I know that sense is a type of meaning)
'north in the southeast again' is the wordplay.
'north' becomes 'N' (abbreviation).
'in the' means one lot of letters goes inside another.
'southeast' becomes 'SE' (synonyms).
'again' becomes 'se' (I can't justify this - if you can you should believe this answer much more).
'se'+'se'='sese'
'n' placed inside 'sese' is 'SENSE'.
'to go' acts as a link.
I am not very happy about this link. Some or all of it may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for sense that I've seen before include "Perceive, detect" , "Realistic attitude" , "reasonable" , "Meaning; perception" , "Divine" .)