Medication to dispose of male's spots (5,5)
I believe the answer is:
epsom salts
'medication' is the definition.
(epsom salts is a kind of medication)
'dispose of male's spots' is the wordplay.
'dispose of' indicates anagramming the letters.
'males'+'spots'='malesspots'
'malesspots' is an anagram of 'EPSOM SALTS'.
'to' is the link.
(Other definitions for epsom salts that I've seen before include "They should clear out!" , "Medicinal preparation" , "Purgative" , "a purge" , "Medicine taken for heartburn and constipation" .)