Men’s general appearance remarked on (4)
I believe the answer is:
guys
'men's' is the definition.
(guy can informally mean a man)
'general appearance remarked on' is the wordplay.
'general appearance' becomes 'guise' (guise can mean appearance).
'remarked on' shows a homophone (sound like) (how it might sound if spoken about or remarked on).
'guise' sounds like 'GUYS'.
(Other definitions for guys that I've seen before include "Fellows" , "Blokes" , "Burn victims" , "Dolls' partners" , "Chaps, lads" .)