Minnesota city street with university crossed by friend (2,4)
I believe the answer is:
st paul
'minnesota city' is the definition.
(St Paul is the capital of Minnesota)
'street with university crossed by friend' is the wordplay.
'street' becomes 'st' (abbreviation).
'with' is a charade indicator (letters next to each other).
'university' becomes 'u' (abbreviation for university).
'crossed by' is an insertion indicator (inserted letters are crossed or covered by others).
'friend' becomes 'pal' (pal can mean a friend).
'u' going into 'pal' is 'paul'.
'st'+'paul'='ST PAUL'
(Other definitions for st paul that I've seen before include "Minnesota capital; martyr" , "US capital" , "He wrote letters to the Corintians and others" , "Apostle of Tarsus" , "He wrote letters to the Corinthian and others" .)