You need skill, in charge of large lorry (5)
I believe the answer is:
artic
'large lorry' is the definition.
(short for articulated lorry)
'you need skill in charge' is the wordplay.
I cannot really understand how this works, but
'skill' could be 'art' (both can mean a talent) and 'art' is present in the answer.
'in charge' could be 'ic' (abbreviation for 'in charge') and 'ic' is located in the answer.
This accounts for all the letters.
This may be the basis of the clue (or it may be nonsense).
'of' acts as a link.
(Other definitions for artic that I've seen before include "Large lorry" , "Large truck (informal)" , "Large vehicle" , "Polar region" , "This transports freight" .)