Misunderstanding unfortunately denigrates me (12)
I believe the answer is:
disagreement
'misunderstanding' is the definition.
(thesaurus)
'unfortunately denigrates me' is the wordplay.
'unfortunately' indicates anagramming the letters (a bad or unfortunate spelling).
'denigrates'+'me'='denigratesme'
'denigratesme' with letters rearranged gives 'DISAGREEMENT'.
(Other definitions for disagreement that I've seen before include "Conflict" , "dispute" , "Argument" , "Quarrel" , "Lack of consensus" .)