Most of county setter originally described as destitute (6)
I believe the answer is:
devoid
'destitute' is the definition.
(I know that destitute can be written as devoid)
'most of county setter originally described' is the wordplay.
'most of' means to remove the last letter.
'county' becomes 'Devon' (I've seen this before).
'setter' becomes 'I' (the person that set the crossword).
'originally described' becomes 'd' (I can't justify this - if you can you should believe this answer much more).
'devon' with its last letter taken off is 'devo'.
'devo'+'i'+'d'='DEVOID'
'as' acts as a link.
Can you help me to learn more?
(Other definitions for devoid that I've seen before include "Lacking or free from" , "Free (of something)" , "Empty or free from" , "Completely lacking" , "Empty - do dive (anag)" .)