Crossword Genius

Most of his arm hurt with vaccine number two (4-8)

Ross

I believe the answer is:

vice-chairman

'number two' is the definition.
(number two in charge)

'most of his arm hurt with vaccine' is the wordplay.
'most of' means to remove the last letter.
'hurt with' is an anagram indicator.
'his' with its last letter taken off is 'hi'.
'hi'+'arm'='hiarm'
'hiarm' mixed up with 'vaccine' can make 'VICE-CHAIRMAN'.

(Another definition for vice-chairman that I've seen is " Committee deputy".)

I've seen this clue in The Telegraph.
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