Most of UK in plague (6)
I believe the answer is:
blight
'plague' is the definition.
(synonyms)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for blight that I've seen before include "Disease of plants etc" , "Curse - plague" , "Disease or fungus that withers plants, say potatoes" , "Shrivelling disease" , "Plant disease or malign influence" .)