Moved twistily, heading off out of cover (5)
I believe the answer is:
naked
'out of cover' is the definition.
(uncovered or unclothed)
'moved twistily heading off' is the wordplay.
'moved twistily' becomes 'snaked'.
'heading off' means to remove the first letter.
'snaked' with its first letter taken off is 'NAKED'.
(Other definitions for naked that I've seen before include "unprotected" , "being exposed" , "Au naturel" , "Bare" , "Defenceless" .)