Mystery in game (6)
I believe the answer is:
enigma
'mystery in game' is the definition.
'enigma' can be an answer for 'mystery' (synonyms). I am not sure about the 'in game' bit.
'mystery in game' is the wordplay.
'mystery' indicates an anagram.
'in'+'game'='ingame'
'ingame' is an anagram of 'ENIGMA'.
Can you help me to learn more?
(Other definitions for enigma that I've seen before include "German military cipher machine" , "Mysteriously puzzling person or thing" , "Mysterious puzzle" , "'Puzzle, riddle (6)'" , "Solution to mystery" .)