No more trouble for you and me - it's mighty (8)
I believe the answer is:
enormous
'mighty' is the definition.
(thesaurus)
'no more trouble for you and me' is the wordplay.
'trouble' is an anagram indicator.
'for' says to put letters next to each other.
'you and me' becomes 'us' (**).
'no'+'more'='nomore'
'nomore' is an anagram of 'enormo'.
'enormo'+'us'='ENORMOUS'
'it's' acts as a link.
(Other definitions for enormous that I've seen before include "Mammoth" , "Unusually large - jumbo" , "Immense" , "Extremely large" , "'Huge, gigantic (8)'" .)