Nominally, she makes a change in the programme (5)
I believe the answer is:
morag
'a change in the programme' is the definition.
I don't know anything about this answer so I can't tell whether it can be defined by this definition.
'nominally she' is the wordplay.
'nominally' becomes 'mor' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'she' becomes 'Ag'.
'mor'+'ag'='MORAG'
'makes' is the link.
Can you help me to learn more?
(Other definitions for morag that I've seen before include "Girl in Scotland" , "Scottish girl's name" , "Scottish girl" , "Second-most famous monster supposedly living in a loch in Scotland" .)