Not be affected by strange American I observe (4,5)
I believe the answer is:
rise above
'not be affected' is the definition.
I know nothing about this answer so I can't tell whether it can be defined by this definition.
'strange american i observe' is the wordplay.
'strange' indicates anagramming the letters.
'american' becomes 'a' (common abbreviation - e.g. in organisation names).
'a'+'i'+'observe'='aiobserve'
'aiobserve' is an anagram of 'RISE ABOVE'.
'by' is the link.
Can you help me to learn more?
(Another definition for rise above that I've seen is " Overcome".)