Not entirely straightforward to look after soap setting (4,3)
I believe the answer is:
east end
'soap setting' is the definition.
(EastEnders is a British soap opera)
'not entirely straightforward to look after' is the wordplay.
'not entirely' means to remove the last letter (not all of the word).
'straightforward' becomes 'easy' (easy can mean straightforward or simple).
'to look after' becomes 'tend' (tending is a kind of looking after).
'easy' with its final letter taken away is 'eas'.
'eas'+'tend'='EAST END'
(Other definitions for east end that I've seen before include "Area of London, featured in a TV soap opera" , "London Cockney area" , "Cockney's part of London" , "Side of London associated with Cockneys (4.3)" , "ockney London" .)