Novel artily involving the Queen should be well-read (8)
I believe the answer is:
literary
'well-read' is the definition.
(thesaurus)
'novel artily involving the queen' is the wordplay.
'novel' indicates anagramming the letters.
'involving' is an insertion indicator.
'the queen' becomes 'er' (Elizabeth Regina).
'artily' with letters rearranged gives 'litary'.
'litary' enclosing 'er' is 'LITERARY'.
'should be' is the link.
(Other definitions for literary that I've seen before include "Concerning written material" , "The scholarly type" , "collection of editions of books" , "well read" , "Learned" .)