One familiar relative of Osiris (4)
I believe the answer is:
isis
'osiris' is the definition.
(thesaurus)
'one familiar relative' is the wordplay.
'one' becomes 'i' (Roman numeral).
'familiar relative' becomes 'sis' (short for sister. I am not sure about the 'familiar' bit.).
'i'+'sis'='ISIS'
'of' is the link.
Can you help me to learn more?
(Other definitions for isis that I've seen before include "divinity" , "banker in Oxford" , "Sister of Osiris" , "Egyptian goddess - Thames at Oxford" , "Oxford's second crew" .)